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This diagnostic plugin would also be invaluable to a physician by offering a simple tool to track a patient’s iron removal progress definitively and measurably. The development of an OsiriX plugin is now needed to simplify and speed up the process. Remi Kessler was instrumental in developing this novel whole-brain quantification technique. Susceptibility-weighted imaging (SWI) is a 3D high-spatial-resolution fully velocity corrected gradient-echo MRI sequence sensitive to hemosiderin, which distorts the local magnetic field, making it a preferred method. The research team identified the need for a software tool sensitive enough to measure the amount of existing iron and detect even the smallest differences over time in a reliable, reproducible, and quantifying MRI measure applied in a blinded fashion validated across multiple centers.
To correct this situation, the team began developing the parameters needed to create a software plugin for use with the OsiriX DICOM viewer to measure the exact amount of iron deposits with a 3D visual. MRI sequencing is required to track existing hemosiderin levels characterized as a rim of low signal covering the brain’s subpial surfaces, brainstem, and spinal cord. Physicians had submitted the participants’ MRIs during several stages of the research differences in MRI equipment, sequencing settings, and magnification produced data that was difficult, if not sometimes impossible, to compare. When a Two-year observational study on the efficacy of deferiprone 1 was released, one finding stood out.
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